Your skin is reacting to the treatment. Is that normal?

You have started a cream or gel containing a retinoid, and your skin is dry, red or flaky. Do not be alarmed: in the first weeks this is usually part of the process. It means the treatment is working, not that something is wrong.

Written by the 247dermatologist editorial team, medically reviewed by dr. A.M. van Coevorden, dermatologist

Reviewed on 29 July 2026± 3 min read

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Why your skin protests at first

Retinoids speed up the renewal of your skin. Your skin needs to get used to that, and this adjustment takes two to six weeks on average. During that period your skin can be drier, redder and more sensitive than usual. Some people even see slightly more pimples at first. That too is well known and passes.

How to make the starting period manageable

Apply the treatment in the evening on dry skin, and use a small amount; applying more does not work better. Wash your face with a mild cleanser, use a neutral rich day cream against the dryness, and protect your skin with sunscreen during the day. Beyond that, follow the build-up schedule in your treatment plan.

This is normal, this is not

Normal in the first weeks: dryness, flaking, mild redness, a slight burning sensation after applying, and temporarily a few more pimples.

Not normal: blisters, severe pain, swelling or redness that spreads. Stop applying and contact your dermatologist.

When will you see results

Not after a week, and that is how it should be. The effect of an acne treatment is only assessed after six to twelve weeks. So do not stop too early; most people who give up do so just before the result becomes visible. If you see no improvement at all after twelve weeks, your dermatologist looks at an adjustment with you.

Important during pregnancy

Do not use retinoids during pregnancy or when trying to become pregnant. If you are pregnant or want to be, always tell your doctor; there are alternatives.

Unsure about your skin?

Not sure whether your skin reaction is normal? Send photos via the app; a dermatologist looks at it with you within 12 to 48 hours.

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Frequently asked questions

My acne is getting worse at first. Is that normal?

Yes, a temporary flare-up in the first weeks does occur. If the worsening lasts longer than six to eight weeks, have it looked at.

Can I stop if my skin gets irritated?

Preferably do not stop on your own. Often building up more slowly or using extra rich cream is enough. When in doubt, consult your dermatologist; they will adjust the schedule.

Can I use retinoids in summer?

Yes, with daily sun protection. Your skin is more sensitive to the sun during treatment, so sunscreen is not optional but a fixed part of it.

Sources

NVDV Acne Guideline
NHG Practice Guideline Acne

Last revised on 29 July 2026

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